Brandon, a thirty-something man living in New York, eludes intimacy with women but feeds his deepest desires with a compulsive addiction to sex. When his younger sister temporarily moves into his apartment, stirring up bitter memories of their shared painful past, Brandon's life, like his fragile mind, gets out of control.

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Michael Fassbender

Brandon

Carey Mulligan

Sissy

James Badge Dale

David

Nicole Beharie

Marianne

Lucy Walters

Woman on Subway Train

Mari-Ange Ramirez

Alexa

Alex Manette

Steven

Hannah Ware

Samantha

Elizabeth Masucci

Elizabeth

Rachel Farrar

Rachel

Michael Fassbender — Brandon

Michael Fassbender (German pronunciation:[ˈmɪçaːʔeːl 'fasbɛndɐ]; born 2 April 1977) is a German-Irish actor. His accolades include nominations for two Academy Awards, four British Academy Film Awards and three Golden Globe Awards. In 2020, he was listed at number nine on The Irish Times list of Ireland's greatest film actors.

Carey Mulligan — Sissy

Carey Hannah Mulligan (born 28 May 1985) is an English actress. She has received various accolades, including a British Academy Film Award, in addition to nominations for three Academy Awards, four Golden Globe Awards, and a Tony Award. She was appointed Commander of the Order of the British Empire (CBE) in 2025 for services to drama.

James Badge Dale — David

James Badge Dale (born May 1, 1978) is an American actor who starred in the AMC drama series Rubicon. He is most famous for his role of Chase Edmunds in the third season of 24 and Robert Leckie in the HBO miniseries The Pacific.