College "frenemies" Lauren and Katie move in together after losing a relationship and rent control, respectively. Sharing Katie's late grandmother's apartment in New York City, the girls bicker with each other until one fateful night, when Katie's noisy bedroom activities make Lauren barge in and discover a dirty little secret. This revelation brings them closer together, and Lauren (the brains) and Katie (the talent) concoct a wildly successful business venture. As profits swell, the girls reevaluate their hopes and dreams and realize that just because someone pees in your hair in college doesn't mean she won't be your best friend 10 years later.

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Ari Graynor

Katie Steel

Lauren Miller Rogen

Lauren Powell

Justin Long

Jesse

Mark Webber

Sean

Mimi Rogers

Adele

Don McManus

Scott

Nia Vardalos

Rachel Rodman

Seth Rogen

Jerry

Veronika Dash

Bridgette

James Wolk

Charlie

Ari Graynor — Katie Steel

Ariel Geltman Graynor (born April 27, 1983) is an American actress. She is best known for her roles in the television series The Sopranos (2001), Fringe (2009–2010), Bad Teacher (2014), I'm Dying Up Here (2017), and Monsters: The Lyle and Erik Menendez Story (2024). In film, she has starred in Nick & Norah's Infinite Playlist (2008), The Sitter (2011), For a Good Time, Call... (2012), and The Disa

Lauren Miller Rogen — Lauren Powell

Lauren Anne Miller Rogen (born July 24, 1981) is an American actress, comedian, screenwriter, and director. She has appeared in the films Superbad (2007), Zack and Miri Make a Porno (2008) and 50/50 (2011). In 2012, she starred in the film For a Good Time, Call..., which she also co-wrote and produced, and in 2018 made her directorial debut with Like Father.

Justin Long — Jesse

Justin Jacob Long (born June 2, 1978) is an American actor, comedian, director and screenwriter. He is known for his work in comedies (like Accepted and Dodgeball) and horror films (like Jeepers Creepers, Barbarian, and Weapons). In recent years, he has been labeled a scream king.