Italian immigrant Francesca Cabrini arrives in 1889 New York City and is greeted by disease, crime, and impoverished children. Cabrini sets off on a daring mission to convince the hostile mayor to secure housing and healthcare for society's most vulnerable. With broken English and poor health, Cabrini uses her entrepreneurial mind to build an empire of hope unlike anything the world had ever seen.

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Cristiana Dell'Anna

Francesca Cabrini

David Morse

Archbishop Corrigan

Giancarlo Giannini

Pope Leo XIII

John Lithgow

Mayor Gould

Romana Maggiora Vergano

Vittoria

Federico Ielapi

Paolo

Virginia Bocelli

Aria

Rolando Villazón

Disalvo

Jeremy Bobb

Calloway

Federico Castelluccio

Senator Bodio

Cristiana Dell'Anna — Francesca Cabrini

Born in Naples, the daughter of a doctor and a teacher, Dell'Anna grew up between Castel Volturno and Giugliano in Campania. She studied at the Drama Studio London and the Guildhall School of Music and Drama.

David Morse — Archbishop Corrigan

David Bowditch Morse (born October 11, 1953) is an American actor. Morse became widely known for his role as Dr. Jack "Boomer" Morrison in the NBC medical drama series St. Elsewhere (1982–88). Some other notable roles are in The Negotiator, The Good Son, Horns, Contact, The Green Mile, Dancer in the Dark, Disturbia, The Hurt Locker, The Long Kiss Goodnight, The Rock and 12 Monkeys.

Giancarlo Giannini — Pope Leo XIII

Giancarlo Giannini (Italian: [dʒaŋˈkarlo dʒanˈniːni]; born 1 August 1942) is an Italian actor. He won the Cannes Film Festival Award for Best Actor for his performance in Love and Anarchy (1973) and received an Academy Award nomination for Seven Beauties (1975). He is also a four-time recipient of the David di Donatello Award for Best Actor.