Elsa and Clive, two rebellious young scientists, defy legal and ethical boundaries and forge ahead with a dangerous experiment: splicing together human and animal DNA to create a new organism. Named "Dren", the creature rapidly develops from a deformed female infant into a beautiful but dangerous winged human-chimera, who forges a bond with both of her creators — only to have that bond turn deadly.

Where to watch it in Canada

For rent

CosmoGo

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Cast

Adrien Brody

Clive Nicoli

Sarah Polley

Elsa Kast

Delphine Chanéac

Dren

Brandon McGibbon

Gavin Nicoli

Simona Măicănescu

Joan Chorot

David Hewlett

William Barlow

Abigail Chu

Child Dren

🎭

Doug Hicton

Lab tech (uncredited)

Adrien Brody — Clive Nicoli

Adrien Nicholas Brody (born April 14, 1973) is an American actor and visual artist. Prolific in both independent films and blockbusters, he has received various accolades, including two Academy Awards, a BAFTA Award, and a Golden Globe Award, with nominations for three Emmy Awards and a Laurence Olivier Award. In 2025, Time magazine listed him as one of the world's 100 most influential people.

Sarah Polley — Elsa Kast

Sarah Ellen Polley OC (born January 8, 1979) is a Canadian filmmaker, political activist and retired actress. She first garnered attention as a child actress for her role as Ramona Quimby in the television series Ramona, based on Beverly Cleary's books. This subsequently led to her role as Sara Stanley in the Canadian television series Road to Avonlea (1990–1996). She has starred in many feature f

Delphine Chanéac — Dren

Delphine Chanéac is a French model, actress and disc jockey. Chanéac worked in the French cinema, appearing in European films and television in the late 1990s and 2000s. She is best known for her role as Pauline in the French sitcom La Vie Devant Nous and for portraying the genetic hybrid Dren in the Canadian science fiction/horror movie Splice, shaving her head for the role. She also starred in t